By: Melanie Ohi, University of Michigan and Michael Cianfrocco, University of Michigan

Cryo-electron microscopy resolution continues to improve. Veronica Falconieri, Sriram Subramaniam, National Cancer Institute, National Institutes of Health, CC BY-NC
Many people will never have heard of cryo-electron microscopy before the announcement that Jacques Dubochet, Joachim Frank and Richard Henderson had won the 2017 Nobel Prize in chemistry for their work developing this technology. So what is it, and why is it worthy of this honor?
Cryo-electron microscopy – or cryo-EM – is an imaging technology that allows scientists to obtain pictures of the biological “machines” that work inside our cells. Most amazingly, it can reconstruct individual snapshots into movie-like scenes that show how protein components of these biological machines move and interact with each other.
It’s like the difference between having a list of all of the individual parts of an engine versus being able to see the engine fully assembled and running. The parts list can tell you a lot, but there’s no replacement for seeing what you’re studying in action.


Stephen Maldonado is an associate professor at the University of Michigan, where he leads a research group that focuses on the study of heterogeneous charge transfer processes relevant to the fields of electronics, chemical sensing, and energy conversion/storage technologies. He was recently reappointed as an associate editor for the
Lithium batteries made with asphalt could charge 10 to 20 times faster than the commercial lithium-ion batteries currently available.
It’s been a busy summer for open access (OA) in Europe. On one hand, nationally coordinated efforts in places like Finland and Germany have sought (unsuccessfully so far) to pressure Elsevier into better subscription pricing and OA options. On the other hand, a group of early career researchers (ECRs) at the University of Cambridge are looking to mobilize fellow ECRs to embrace open models that are not controlled by commercial entities. In my view, these divergent approaches illustrate why we should focus our collective energies away from strategies in which commercial interests retain control under new economic conditions (see also, proposals to flip subscription payments to APCs), and towards working with ECRs and others who envision a return of scholarly dissemination responsibility to the academy.
Since the
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