Sensing technology plays a pivotal role in achieving health and environmental sustainability goals, as outlined by the United Nations. To support these goals, sensors must deliver reliable, context-specific performance, allowing effective decision-making at critical points of need. In this regard, next-generation sensing technologies are emerging as a promising tool. These advanced systems integrate functionalized materials with tunable properties, miniaturized electronics, efficient data management, AI-driven algorithms, and sophisticated data analytics to enable intelligent decision-making and risk assessment. However, the concept of next-generation sensing, which represents a leap toward highly integrated, intelligent sensing solutions, remains underexplored due to its complex, multidisciplinary challenges.